Dyvon® Ointment 20gm – 1 Pcs

Name: Dyvon® Ointment 20gm - 1 Pcs
SKU: 211295
Price: 351.06 BDT
Availability: InStock

Generic Name: Calcipotriol
Non-steroid (Topical Preparations)

Manufacturer:Square Pharmaceuticals Ltd.

৳ 351.06

Indications

Calcipotriol ointment is indicated for the treatment of plaque psoriasis, Scalp psoriasis, Alopecia areata in adults.

Therapeutic Class

Topical Vitamin D & related preparations

Pharmacology

Calcipotriol is a non-steroidal antipsoriatic agent, derived from vitamin D. Calcipotriol exhibits a vitamin D-like effect by competing for the 1,25(OH)2D3 receptor. Calcipotriol is as potent as 1,25(OH)2D3, the naturally occurring active form of vitamin D, in regulating cell proliferation and cell differentiation, but much less active than 1,25(OH)2D3 in its effect on calcium metabolism. Calcipotriol induces differentiation and suppresses proliferation (without any evidence of a cytotoxic effect) of keratinocytes, thus reversing the abnormal keratinocyte changes in psoriasis. The therapeutic goal envisaged with calcipotriol is thus a normalization of epidermal growth.

Dosage & Administration

Adults: Calcipotriol cream, ointment or Scalp solution should be applied topically to the affected area twice daily (i.e. in the morning and in the evening). Less frequent application may be indicated after the initial period of treatment. After satisfactory improvement has occurred, treatment should be discontinued. If recurrence takes place after discontinuation, the treatment may be reinstituted. Experience is lacking in the use of calcipotriol for periods longer than 1 year. The maximum recommended weekly dose of calcipotriol cream is 100gm/week. Children: Calcipotriol cream, ointment or Scalp solution should not be used in children, as there is inadequate experience with its use.

Contraindications

Calcipotriol cream & ointment is contraindicated in those patients with a history of hypersensitivity to any of the components of the preparations. It is also contraindicated in patients with known disorders of calcium metabolism.

Side Effects

The most frequent adverse experiences reported for Calcipotriol ointment were cases of skin irritation, which occurred in approximately 10-15% of patients. Rash, pruritus, dermatitis and worsening of psoriasis were reported in 1 to 10% of patients. Other experiences reported in less than 1% of patients included skin atrophy, hyperpigmentation, hypercalcemia, and folliculitis.

Pregnancy & Lactation

Pregnancy: Safety for use in pregnancy has not been established. Therefore calcipotriol should not be used during pregnancy unless benefits clearly outweigh the risks. Lactation: It is not known whether calcipotriol is excreted in breast milk, therefore, the drug should be used during lactation only if the benefits clearly outweigh the risks. Calcipotriol should not be applied to the chest area during breast feeding to avoid possible ingestion by infants.

Precautions & Warnings

Use of Calcipotriol ointment may cause irritation of lesions and surrounding uninvolved skin. If irritation develops, Calcipotriol ointment should be discontinued. Transient, rapidly reversible elevation of serum calcium has occurred with use of Calcipotriol ointment. If elevation in serum calcium outside the normal range occurs, discontinue treatment until normal calcium levels are restored.

Overdose Effects

Topically applied Calcipotriol can be absorbed in sufficient amounts to produce systemic effects. Elevated serum calcium has been observed with excessive use of topical Calcipotriol. If elevation in serum calcium should occur, discontinue treatment until normal calcium levels are restored.